People
Molly Shoichet
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Project
I graduated with a BSc in Molecular Biology and Biochemistry from Durham University (UK) and then undertook a Wellcome Trust funded CASE PhD in the Przyborski laboratory at Durham University. My PhD focused on how peptide motifs can be used to control cell fate. I currently hold an Ontario Neurotrauma Foundation post-doctoral fellowship aimed at using biomaterials to increase cell survival following transplantation. Current transplantation strategies are limited by poor cell survival. I am investigating how biomaterials can be used to promote cell survival in the central nervous system.
Awards
ONF PDF 2009-2011
BBSRC PhD. CASE Studentship PhD 2005-2008
Wellcome Trust Vacation Scholarship 2004
Publications
Soft Matter 6: 4988-98
Author(s): M. J. Cooke, K. Vulic, M. S. Shoichet,
Design of biomaterials to enhance stem cell survival when transplanted into the damaged central nervous system
Biomaterials 31 (9), pp. 2555-2564
Ballios, B.G., Cooke, M.J., van der Kooy, D., Shoichet, M.S.
A hydrogel-based stem cell delivery system to treat retinal degenerative diseases
Journal of Biomedical Materials Research - Part A 93 (3), pp. 824-832
MJ Cooke, T Zahir, SR Phillips, DSH Shah, D Athey, JH Lakey, MS Shoichet, SA Przyborski.
Regulation of neurogenesis by biomimetic surfaces presenting motifs of extracellular matrix proteins.
Stem Cell Research 2; 3; 2009, 188-197
Paul A. De Sousa, John Gardner, Sharon Sneddon, Steve Pells, Britt Jorgensen Tye, Pawlina Dand, Daniel M. Collins, Karen Stewart, Lisa Shaw, Stefan Przyborski, Michael Cooke, K. John McLaughlin, Susan J. Kimber, Brian A. Lieberman, Ian Wilmut, Daniel R. Brison.
Clinically failed eggs as a source of normal human embryo stem cells
Journal of Cell Biology Jan 12;184(1):67-82
Xin Zhang, Irina Neganova, Stefan Przyborski, Chunbo Yang, Michael Cooke, Stuart Atkins, George Anyfantis, Stefan Fenyk, W. Nicol Keith, Stacey F. Hoare, Owen Hughes, Tom Strachan, Miodrag Stojkovic, Lyle Armstrong, and Majlinda Lako.
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.
Stem Cells Apr;26(4):850-63
Chunbo Yang, Stefan Pryzborski, Michael J Cooke, Xin Zhang, Rebecca Stewart, Stuart Atkinson, Gabriele Saretzki, Lyle Armstrong and Majlinda Lako.
A key role for telomerase reverse transcriptase unit (TERT) in modulating human ESC proliferation, cell cycle dynamics and in vitro differentiation.
Cytotechnology 56 (2):71-79
M J. Cooke, S. R. Phillips, D S H. Shah, D. Athey, J H. Lakey, S A Przyborski.
Enhanced cell attachment using a novel cell culture surfaces presenting functional domains from extracellular matrix proteins.
Stem Cells and Development 15(2):254-9
Cooke MJ, Stojkovic M, Przyborski SA.
Growth of teratomas derived from human pluripotent stem cells is influenced by the graft site.
Stem Cells 24(12):2669-76
Zhang X, Stojkovic P, Przyborski S, Cooke M, Armstrong L, Lako M, Stojkovic M.
Derivation of human embryonic stem cells from developing and arrested embryos.
Conferences
ISSCR (San Francisco, USA) – Poster presentation
Neural Stem/Progenitor Cell Delivery to the Central Nervous System
EuroSciCon, Developments in cell culture technology to enhance cell growth in vitro (Welwyn Garden City, UK) – Oral presentation
Controlling cell attachment and development using extracellular matrix motifs presented by biomimetic surfaces
Gordon Research Conference, Signal Transduction by Engineered Extracellular Matricies (Lewiston, USA) – Poster presentation
Development of biomimetic surfaces that modulate cell adhesion and differentiation
Anatomy Society Seminar (Durham, UK) – Poster presentation
Presentation of Extracellular Matrix motifs by Biomimetic Substrates to Control Cellular Attachment and Differentiation.
British Neuroscience Seminar (Harrogate, UK) – Poster presentation
Development of biomimetic substrates to control the attachment and differentiation of neural cells.
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