Our research program requires a cross disciplinary approach where aspects of
engineering, chemistry, and biology are applied to the fields of Regenerative Medicine,
Tissue Engineering and Drug Delivery. We approach unsolved problems in medicine by
creating a series of design criteria which we then use to formulate solutions.
Our laboratory has designed novel injectable hydrogels for local delivery to the injured
spinal cord and brain. We have created novel polymeric nanoparticles for targeted
delivery in cancer. We have pursued tissue engineered 3-dimensional constructs to
spatially control cell differentiation, using multiphoton laser excitation and advanced
photochemistry to design defined chemical matrices. We have explored cell
transplantation strategies using tubular scaffolds and injectable materials. While the
laboratory is pursuing a diversity of projects, they are linked by the common theme of
polymeric design for medical application.
Our multidisciplinary projects benefit from collaborations with scientists with
complementary expertise, in stem cell biology, neurosurgery and cancer. The laboratory
is funded primarily by the Natural Sciences and Engineering Council of Canada, the
Canadian Institutes of Health Research, the Ontario Centers of Excellence, the Heart &
Stroke Foundation (Ontario), McEwen Center in Regenerative Medicine, Krembil
Neuroscience Foundation, Advanced Food & Materials Network, NCE, among others.