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Research Overview
Targeted Delivery
Injectable Hydrogels
3-D Scaffolds
Cell Delivery
Funding Partners

 

Research Overview

Our research program requires a cross disciplinary approach where aspects of
engineering, chemistry, and biology are applied to the fields of Regenerative Medicine,
Tissue Engineering and Drug Delivery. We approach unsolved problems in medicine by
creating a series of design criteria which we then use to formulate solutions.

Our laboratory has designed novel injectable hydrogels for local delivery to the injured
spinal cord and brain. We have created novel polymeric nanoparticles for targeted
delivery in cancer. We have pursued tissue engineered 3-dimensional constructs to
spatially control cell differentiation, using multiphoton laser excitation and advanced
photochemistry to design defined chemical matrices. We have explored cell
transplantation strategies using tubular scaffolds and injectable materials. While the
laboratory is pursuing a diversity of projects, they are linked by the common theme of
polymeric design for medical application.

Our multidisciplinary projects benefit from collaborations with scientists with
complementary expertise, in stem cell biology, neurosurgery and cancer. The laboratory
is funded primarily by the Natural Sciences and Engineering Council of Canada, the
Canadian Institutes of Health Research, the Ontario Centers of Excellence, the Heart &
Stroke Foundation (Ontario), McEwen Center in Regenerative Medicine, Krembil
Neuroscience Foundation, Advanced Food & Materials Network, NCE, among others.


  Targeted Delivery: With the synthesis of a novel biodegradable polymer that self-
assembles in water to nanoparticles, we have investigated the power of Diels-Alder
chemistry for the immobilization of antibodies and their use for targeted delivery in
breast cancer of both antibodies and chemotherapeutics.
MORE

  Injectable Hydrogels: Using a physical blend of hyaluronan and methyl cellulose,
we have achieved local and sustained delivery to the injured spinal cord and stroke-
injured brain demonstrating some therapeutic and tissue benefit.
MORE

  3-D Scaffolds: To guide cells (and axons), both haptotactic and chemotactic cues have
been incorporated into 3-dimensional hydrogels using photochemistry and laser
technology. Haptotactic cues include cell adhesive peptides. Chemotactic cues include
concentration gradients of growth factors.
MORE

  Cell Delivery: We are investigating cell delivery to the brain, retina and spinal cord via a
minimally-invasive injectable hydrogel and by implantation of nerve guidance cells.
Polymeric hollow fiber membranes (i.e. porous tubes) have been synthesized with the
mechanical and transport properties required for implantation into the central nervous
systems. To enhance regeneration, we are investigating an in situ drug delivery strategy
to stem cells that reside within.
MORE

 
 

 


Research Overview
Targeted Delivery
Injectable Hydrogels
3-D Scaffolds
Cell Delivery
Funding Partners
Targeted Delivery: With the synthesis of a novel biodegradable polymer that self-assembles in water to nanoparticles, we have investigated the power of Diels-Alder chemistry for the immobilization of antibodies and their use for targeted delivery in breast cancer of both antibodies and chemotherapeutics. MORE






Research Overview
Targeted Delivery
Injectable Hydrogels
3-D Scaffolds
Cell Delivery
Funding Partners

Injectable Hydrogels: Using a physical blend of hyaluronan and methyl cellulose, we have achieved local and sustained delivery to the injured spinal cord and stroke-injured brain demonstrating some therapeutic and tissue benefit.





Research Overview
Targeted Delivery
Injectable Hydrogels
3-D Scaffolds
Cell Delivery
Funding Partners

3-D Scaffolds: To guide cells (and axons), both haptotactic and chemotactic cues have been incorporated into 3-dimensional hydrogels using photochemistry and laser technology. Haptotactic cues include cell adhesive peptides. Chemotactic cues include concentration gradients of growth factors.



Research Overview
Targeted Delivery
Injectable Hydrogels
3-D Scaffolds
Cell Delivery
Funding Partners

Cell Delivery: We are investigating cell delivery to the brain, retina and spinal cord via a minimally-invasive injectable hydrogel and by implantation of nerve guidance cells. Polymeric hollow fiber membranes (i.e. porous tubes) have been synthesized with the mechanical and
transport properties required for implantation into the central nervous systems. To enhance regeneration, we are investigating an in situ drug delivery strategy to stem cells that reside within.